The Impact of Combined (Aerobic-resistance) Training on Serum Levels of IGF-I and IGFBP-۳ in Men with Prostate Cancer

Background & Objective: Prostate cancer is the most common cancer in men. The purpose of this study was to determine the effect of combined training (aerobic-resistance) on serum levels of insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding proteins ۳ (IGFBP-۳) in men with prostate cancer. Materials & Methods: ۲۰ eligible men with prostate cancer with an average age of ۶۲.۶±۷.۷۱ years, height of ۱۷۲.۱۵±۵.۰۲ cm, average weight of ۷۵.۶±۱۱.۶ kg, and the body mass index ۲۵.۵۴±۳.۴۷ were divided randomly into two groups (۱۰ individuals each): the control and experimental groups. The experimental group experienced eight weeks of combined training (Aerobic resistance) with three sessions per week. During this period the control group did not participate in any exercise. At the beginning and the end of the period, ۵ mL blood samples were taken to measure serum levels of IGF-I and IGFBP-۳. The obtained data were then analyzed using ANCOVA with P-value≤ ۰.۰۵. Results: The results showed that the eight weeks of combined training significantly reduced the level of IGF-I in the experimental group (P=۰.۰۰۱). Also, the combined training significantly increased the level of IGFBP-۳ in the experimental group, which was significantly different from the control group (P=۰.۰۳۶). Conclusion: The results of this study indicate that the combined training can affect some of the factors associated with prostate cancer and may be able to contribute to the improvement of patientschr('۳۹') disease (along with the main treatment protocol).

کلیدواژه ها:

ombined training ، Prostate cancer ، IGF-I ، IGFBP-۳