A review of the Anti-inflammatory effects of Mentha pulegium as a possible candidate in the treatment of patients with COVID_۱۹

Background and Aim : One of the major complications in patients with Covid-۱۹ disease is cytokine storm, which is an abnormal immune response that leads to severe pneumonia. TNF-α, IFN-α are important secretory cytokines in this disease, both of which have a synergistic effect in inflammation, lung damage and mortality. Due to the lack of a suitable drug in the treatment of Covid-۱۹ disease, many studies have shown that plant extracts have a variety of biological effects such as immunomodulatory properties. the aim of this study was to review the Anti-inflammatory effects of Mentha pulegium as a possible candidate in the treatment of patients with COVID_۱۹.Methods : The present study is a review study by searching reputable scientific databases such as Pubmed Google scholar, Scopus from ۲۰۱۵ to ۲۰۲۱ using the keywords SARS-COV-۲, Covid-۱۹, TNF-α, IFN-γ, cytokine storm , Treatment, Anti-inflammatory Latest information obtained.Results : In this study, ۳۰ articles were reviewed, Therefore, Mentha pulegium plant has anti-inflammatory activity with effective compounds such as alkaloids, flavonoids, thymol and carvacrol. The results of these studies as invitro-invivo confirm the therapeutic effects of Mentha pulegium.Conclusion : Due to the widespread prevalence of Covid_۱۹ disease and secretion of TNF-α, IFN-γ, which can cause shock due to further spread of lung damage and subsequent pneumonia, acute respiratory distress syndrome, loss of respiratory control and other organs, and death. Therefore, a drug is needed to block and inhibit these cytokines. Due to having the mentioned active ingredients, oregano Mentha pulegium plant can be evaluated as a possible drug candidate in the treatment of patients with covid_۱۹ clinical trial.

کلیدواژه ها:

Mentha pulegium ، covid-۱۹ ، Anti-inflammatory ، Treatment