Combined effects of aerobic exercises and l-arginine ingestion on total antioxidant capacity (TAC) and C-reactive protein (CRP) in diabetic male rats

Introduction: The aim of present study was to investigate the combined effects of aerobic exercises and l-arginine ingestion on total antioxidant capacity (TAC) and C-reactive protein (CRP) in diabetic male rats.Material & Methods: Analysis method:  ۲۴ male rats (age :۱۲ weeks, weight range of ۲۶۰-۳۶۰ g) were put randomly into ۴ groups of healthy control (n=۶), L-arginine supplement consumption group (n=۶), aerobic exercise group (n=۶) and L-arginine supplement consumption group with aerobic exercise group (n=۶).All of these groups which became diabetic by injection of STZ except the healthy control group were under the study. The aerobic exercise group and L-arginine consumption group and aerobic exercise started walking or running on the treadmill with ۱۰ m/min and slope of ۰° for ۵ sessions of ۱۵ minutes in a week. After each day, ۱ m/min and ۵ minutes were added to their exercise and at the end of the seventh day the speed reached to ۱۶ m/min and the time became ۴۵ minutes.Results: The present results showed that L-arginine supplement consumption made a significant difference between TAC-CRP indicators in supplement and placebo groups. L-arginine supplement consumption made a significant reduction in TAC antioxidant indicator and resulted in CRP increase. TAC antioxidant indicator has an increasing effect on the improvement of total antioxidant capacity of diabetic rats by doing sport exercises but the sport exercises reduce CRP level. Aerobic exercises along with L-arginine supplement consumption didn’t change TAC antioxidant indicator of mature rats a lot and are the same in both exercise and without exercise levels but had a significant difference in CRP levels between aerobic exercise-supplement and placebo groups. Exercise reduced significantly on CRP indicator of mature diabetic rats in supplement consumption situation than placebo situation. On the other hand, there was a significant difference between the mean of CRP antioxidant indicator between supplement consumption without exercise and placebo without exercise.Conclusions: L-arginine supplement resulted in the significant increase of CRP in diabetic mature rats than placebo.