Autophagy Role as a Double-Edged Sword in Anesthesiology and Critical Care
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 121
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شناسه ملی سند علمی:
JR_SBMU-6-1_007
تاریخ نمایه سازی: 9 آبان 1401
چکیده مقاله:
Autophagy is a conserved lysosomal degradation pathway that breaks down cytoplasmic components and is essential for host cellular immune response. The activity of autophagy at a basic rate is crucial for homeostasis. Autophagy has emerged in recent years as a major mechanism in many neurodegenerative diseases. The regulation of microbial infections and inflammatory responses can be significantly influenced by autophagic modulators. In this study, we explain the autophagy role as a double-edged sword in anesthesiology and critical care. Future studies should focus on investigating the molecular mechanism of interplay between pathogen-host-autophagy and on studying whether autophagy inducers/inhibitors can exert suitable modulatory immunomodulatory effects. Potential organ protection through autophagy pathways might be an advantage in patients undergoing anesthesia and/or needing critical care.
کلیدواژه ها:
نویسندگان
Milad Zandi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Maryam Fazeli
Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Parnian Ghadimi
Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Saber Soltani
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Farid Azizi Jalilian
Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Aryan Banai Shahani
Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran