Supplementation with omega-۳ plus vitamin E and zinc plus vitamin C on metabolic syndrome components in postmenopausal women with type ۲ diabetes

Background: The aim of this study was to find the influence of supplementation with omega-۳ plus vitamin E and vitamin C plus zinc on metabolic syndrome components. Methods: In a double-blind controlled clinical trial, ۷۵ diabetic postmenopausal women were randomly assigned to one of the three therapeutic groups of daily supplementation of ۱.۸g omega-۳ plus ۴۰۰mg vitamin E (group A), ۵mg zinc plus ۳۰۰mg vitamin C (group B), or placebo (group C) for ۱۲ weeks and the results were evaluated. Results: One-way repeated measures ANOVA showed that systolic and diastolic blood pressure and waist circumference showed significant difference before and after the intervention (p = ۰.۰۰۰۱, ۰.۰۰۱, and ۰.۰۴۵, respectively). Results of Univariate ANOVA showed that the level of plasma fasting blood sugar (FBS) and HDL-cholesterol significantly increased (p =۰.۰۱ and p =۰.۰۳, respectively) in patients who had been diagnosed as diabetic ≤۷ years in group B. The plasma TG concentration significantly decreased (p =۰.۰۰۷) in patients who had been diagnosed as diabetic ≤۷ years in group A. Systolic and diastolic BP significantly decreased (p =۰.۰۰۵ and p =۰.۰۴, respectively) in patients who had been diagnosed as diabetic ≤۷ years in group A. The most effectiveness of nutraceutical supplementation was on patients that had been diagnosed as diabetic ≤۷ years. Plasma TG and systolic BP decreased with omega-۳ plus vitamin E; however, plasma FBS and HDL- cholesterol increased with zinc plus vitamin C supplementation. Conclusion: Several factors, such as duration of diabetes, age, gender, pathophysiology status, genetic, and other anthropometric characteristics may influence the effectiveness of supplementation.

کلیدواژه ها:

Metabolic syndrome components ، Postmenopausal women ، Supplementation ، Type ۲ diabetes