In Vitro Release Kinetics of Curcumin From Thermosensitive Gelatin-Chitosan Hydrogels Containing Zinc Oxide Nanoparticles
محل انتشار: مجله علم مواد و مهندسی ایران، دوره: 19، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 126
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شناسه ملی سند علمی:
JR_IJMSEI-19-2_008
تاریخ نمایه سازی: 25 دی 1401
چکیده مقاله:
In this paper, chemically-crosslinked gelatin/chitosan hydrogels containg zinc oxide nanoparticles (ZNPs), were loaded with curcumin (CUR), and their microstructural features, physical properties, curcumin entrapment efficiency, and drug release kinetics were evaluated using scanning electron microscopy (SEM), the liquid displacement method, and UV–Vis spectroscopy. The in vitro kinetics of drug release was also studied using First-order, Korsmeyer-Peppas, Hixon-Crowell, and Higuchi kinetic models. The SEM micrographs confirmed the formation of highly porous structures possessing well-defined, interconnected pore geometries. A significant reduction in the average pore sizes of the drug-loaded hydrogels was observed with the addition of ZNPs and CUR to the bare hydrogels. High value of drug loading efficiency (~ ۷۲ %) and maximum drug release of about ۵۰ % were obtained for the drug-loaded scaffolds. It was found that curcumin was transported via the non-Fickian diffusion mechanism. It was also shown that the kinetics of curcumin release was best described in order by Hixon-Crowell, Higuchi, and Korsmeyer-Peppas models, demonstrating that drug release was controlled by diffusion, degradation, and swelling of the drug carrier. However, lower degree of fitting was observed with First-order kinetic model.
کلیدواژه ها:
نویسندگان
Shadi Moshayedi
Iran University of Science and Technology
Hossein Sarpoolaky
Iran University of Science and Technology
Alireza Khavandi
Iran University of Science and Technology
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