Serotype Determination of Streptococcus Agalactiae Detected from Vagina and Urine of Pregnant Women in Yazd, Iran-۲۰۱۵
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 141
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شناسه ملی سند علمی:
JR_JIML-5-1_006
تاریخ نمایه سازی: 7 اسفند 1401
چکیده مقاله:
Background and Aims: Group B streptococcus (GBS), is a bacterium that colonize in the vagina and/or rectum of pregnant, as well as non-pregnant women. The frequency of GBS varies in different geographical areas. Capsular serotyping of the bacterium could result in efficient vaccine designation. Serotyping data of GBS in Iranian pregnant women is limited. The aim of this study was to investigate the GBS molecular capsular serotyping of pregnant women in Yazd, Iran.
Materials and Methods: In this cross-sectional study, a total of ۳۴۶ vaginal and urine samples collected from pregnant women were cultured on blood agar and following incubation, the suspected colonies were identified according to standard protocol. Capsular serotyping was carried out by multiplex-polymerase chain reaction assay.
Results: Three hundred forty six samples were collected from pregnant women out of which ۵۷ (۱۶.۴۷%) and ۳۳ (۹.۵%) samples were identified as GBS of vagina, and urine, respectively. Serotype III was predominant in both vaginal and urine samples by frequencies of ۵۴.۴% and ۵۱.۵ %, respectively. Other serotypes in vaginal GBS were as II (۲۶.۳%), Ia (۱۲.۳%), Ib (۳.۵%), and V (۳.۵%); while in urine GBS were as Ia (۲۱.۲%), II (۱۸.۲%), Ib (۶.۱%), and V (۳%).
Conclusions: This study revealed that capsular serotype III of GBS is the dominant serotype among pregnant women in Yazd, Iran. Moreover vaginal and urine GBS serotypes were significantly correlated. These data could be helpful for future possible formulation of a GBS conjugate vaccine.
نویسندگان
Nilufar Najarian
Department of Microbiology, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohamad Bagher Khalili
Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Akram Astani
Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mahmood Vakili
Department of Public Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Maryam Sadeh
Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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