Long GnRH Agonist versus GnRH Antagonist Protocols in Women with Endometrioma and Good Ovarian Reserve Undergoing IVF/ICSI Cycles

Background: The best ovarian stimulation protocol in the case of endometrioma-related infertility is still debated. In this study, we examined the effect of two ovarian stimulation protocols on in vitro fertilization (IVF)/intra-cytoplasmic sperm injection (ICSI) outcome in patients with good ovarian reserve suffering from endometrioma.Methods: In a retrospective study, ۱۰۱ women with endometrioma and good ovarian reserve were recruited. Women received either gonadotropin-releasing hormone (GnRH) agonists (n=۶۵) or GnRH antagonists (n=۳۶) in an IVF or ICSI cycle. Clinical and chemical pregnancy rate, live birth rate, implantation rate, fertilization rate and fertilization proportion, as well as miscarriage rate, were evaluated in both groups.Results: Chemical (۲۵% vs. ۲۸.۶%), clinical (۱۹.۶% vs. ۲۵%), and live birth rates (۱۹.۶% vs. ۲۵%) as well as implantation rate (۱۱.۷% vs. ۱۵%) were not significantly different between the two groups. Miscarriage rate, fertilization rate and fertilization proportion were similar in the two groups.Conclusion: GnRH antagonist protocol with the main advantages of short duration and lower cost of treatment could be applied in infertile patients with endometrioma and good ovarian reserve.

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Keywords: Endometrioma ، Controlled ovarian hyperstimulation ، GnRH-agonist ، GnRH-antagonist ، Art