Risk of Neonatal Outcomes Associated with COVID-۱۹ Infection during Pregnancy: A Retrospective Cohort Study

Background: Since its announcement as a pandemic, COVID-۱۹ has been shown to be associated with more severe outcomes among pregnant women. Infected mothers may develop Intrauterine Growth Retardation (IUGR), stillbirth, premature labor, and Disseminated Intravascular Coagulation when carrying a child (DIC). The present study aimed to estimate the risk of severe COVID-۱۹ and its correlation with adverse neonatal outcomes among pregnant women. Methods: This was a population-based, retrospective cohort study of all pregnancies with a live birth or fetal death in Mashhad, Iran, from February ۲۰, ۲۰۲۰, to June ۲۱, ۲۰۲۰, on ۴۶۰ patients who tested positive for COVID-۱۹. The assessed neonatal outcomes included preterm birth, IUGR, stillbirth, severe neonatal asphyxia, and neonatal death. Modified Poisson and multinomial logistic regression models were used to derive relative risk estimates. Results: ۴۶۰ patients identified with COVID-۱۹ during pregnancy were assessed in the study. Overall, the most prevalent complication was preterm birth, with a total of ۱۱۹ (۲۵.۹) cases. In multivariable analysis, the risk of preterm labor, low birth weight, severe neonatal asphyxia, ICU-admitted mother, the length of hospitalization> ۷ days and IUGR were significantly increased in the Stillbirth. The risk of global preterm birth had also significantly increased in the Stillbirth group compared to the other group (۹۱.۷% versus ۲۳.۷%, aOR = ۳.۶۶, ۹۵% CI [۸.۸۵- ۱۶۵.۸۷], p < ۰.۰۰۱). Conclusion: Along with the possibility of more severe COVID-۱۹ infection among pregnant women, five complicated outcomes were described in the present study, including preterm birth, IUGR, stillbirth, severe neonatal asphyxia, and neonatal deaths as risk factors of COVID-۱۹ infection in pregnancy.

کلیدواژه ها:

Neonatal Outcomes ، ، ، ، ، COVID-۱۹ Infection ، ، ، ، ، ، Pregnancy ، ، ، ، ، Retrospective Cohort Study