The chemotherapy-induced peripheral neuropathy treatment with novelsystemic ozone therapy method: a case report

Cancer is one of the leading causes of death in the world today. Chemotherapy is promising to overcome it,but chemotherapy accompanies with side effects. Among these side effects can be pointed to chemotherapyinducedperipheral neuropathy (CIPN). CIPN decreases the quality of life of sufferers and increases the costof care. This report mentions a new method based on systemic ozone therapy for the treatment of paincaused by CIPN. A patient with severe pain (NRS score of ۱۰) caused by CIPN was treated with theinnovative method of systemic ozone therapy. This method is based on the use of ozone gas mixture infusionwith a dose of ۵۰ μg/cc with half-saline, and the volume of ozone in the mixture increases up to ۱۰۰ cc duringsubsequent sessions. During ten treatment sessions, the pain score reached about three and showed asignificant decrease.