Failure of monovalent and polyvalent rabies vaccines to induce anti-rabies IgG in dogs as measured using an indirect ELISA

We aimed to investigate the efficacy of current practice of rabies vaccination in dogs of Bangladesh. Pet dogs (n=۲۰) visited Teaching Veterinary Hospital of Chattogram Veterinary and Animal Sciences University were injected with commercially available monovalent or polyvalent vaccines containing inactivated adjuvanted rabies virus. Group of dogs were administered with single dose of monovalent (n=۵) or polyvalent (n=۵) rabies vaccine. Separate group of animals were injected with a second dose (monovalent n=۵, polyvalent n=۵) ۱۴-days after the primary injection. Blood samples were collected at day-۲۸ after the initial injection. Baseline sera were collected before starting injections. Indirect enzyme-linked immunosorbent assay was performed with sera samples to detect anti-rabies IgG. We were unable to detect any anti-rabies IgG titer in the dogs vaccinated with either monovalent or polyvalent vaccines irrespective of frequency of vaccination. The results indicate that the current commercial rabies vaccines are doubtful in generating protective antibody titer in dogs of this area. The results predict public health risk and demand for extensive investigation of vaccine quality and transportation.

کلیدواژه ها:

Rabies ، Vaccination ، Dog ، ELISA ، IgG