Differences in the Expression of CD۴۴ and EMMPRIN in Various Spectra of Mucinous Ovarian Tumors

Mucinous ovarian carcinoma (MOC) accounts for only ۴% of epithelial ovarian carcinoma, but the incidence rate in Indonesia is higher. Mucinous ovarian tumors (MOT) consist of mucinous cystadenoma (MCA), mucinous borderline tumor (MBOT), and MOC, but the diagnosis still needs further study. Carcinogenesis of ovarian cancer involves the regulation of proliferation and invasion. CD۴۴ is a cancer stem cell (CSC) marker that mainly plays a role in tumor cell proliferation. A glycoprotein called EMMPRIN contributes to cancer biology, particularly the invasion process. The objective was to analyze the differences in the expression of CD۴۴ and EMMPRIN in various spectra of MOT. A retrospective cross-sectional study was performed using ۵۳ paraffin blocks from patients with MOT after approval by the Ethical Committee. The samples were divided into ۳ groups, including mucinous cystadenoma (MCA), MBOT, and MOC grade ۱. The expression of CD۴۴ and EMMPRIN were evaluated using semi-quantitative immunohistochemistry method. There were differences in CD۴۴ expression in various spectra of MOT (p=۰.۰۲۵), with significant differences in expression between MCA and MBOT (p=۰.۰۱۰), but there was no correlation (p = ۰.۴۳۲). There was no difference in EMMPRIN expression in various spectra of MOT (p=۰.۲۰۷), and there was no correlation (p=۰.۱۱۳). There was a positive correlation between CD۴۴ expression and EMMPRIN expression in various spectra of MOT (p=۰.۰۰۰۳) with weak strength (r = ۰.۴۷۸). This study concluded that there were significant differences in CD۴۴ expression between MCA and MBOT.

کلیدواژه ها:

CD۴۴ ، EMPPRIN ، Mucinous ovarian tumor ، cancer ، Borderline ovarian tumor