Effect of Protein Corona Formation on Photonic Response of Upconverting Nanoparticles

NaYF۴:Yb,Er is one of the efficient and well-known upconverting materials which emit photoluminescence light at ۵۴۵ nm and ۶۶۰ nm under an excitation of ۹۸۰ nm. In this study, up-conversion nanoparticles using thermal decomposition method have been synthesized and characterized and phase transition from organic to aquas by synthesis a SiO۲ shell have done successfully. The results show that the nonlinearity response of NaYF۴: Yb, Er@SiO۲ is same as NaYF۴: Yb, Er and SiO۲ has no effect on emission peaks it means that these nanoparticles are suitable for biomedical applications. Since it is necessary to know the photoluminescent behavior of UCNPs@SiO۲ particles, thereby the fluorescence properties of up-conversion nanoparticles with SiO۲ shell have been investigated in PBS, normal and cancerous human blood plasma. The results indicate that UCNP@SiO۲ can be applicable in biological medias for therapy and diagnostic.

کلیدواژه ها:

Nonlinear photoresponse ، Upconversion Nanoparticles ، Protein Corona ، Corona Formation ، human blood plasma ، near infrared