Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model

The current study aimed to investigate the neuropharmacological properties of ethanol, acetone, and ethyl acetate leaf extracts of Chassalia curviflora (C. curviflora) in mouse models. The neuropharmacological properties of this plant were studied on Swiss albino mice at dosages of ۵۰, ۱۰۰, and ۲۰۰ mg/kg body weight in thiopental sodium-induced sleeping time test, and at dosages of ۱۰۰ and ۲۰۰ mg/kg body weight in other tests. The extracts caused a marked reduction in the initiation and sleep length (P<۰.۰۵) in studies on thiopental sodium-induced sleeping time at dosages of ۱۰۰ and ۲۰۰ mg/kg and a significant decrease (P<۰.۰۵) was found in terms of unconstrained locomotor and explorative activities in both hole crossing and open field tests at dosages of ۱۰۰ and ۲۰۰ mg/kg. Furthermore, the extracts increased sleeping time with a dosage-dependent onset of action. The hole-board test extracts also reduced the number of head dips at dosages of ۱۰۰ and ۲۰۰ mg/kg (P<۰.۰۵). It was found in this study that C. curviflora had the best neuropharmacological properties at a dosage of ۲۰۰ ml/kg. Our findings also showed that all of the extracts from C. curviflora were experimentally active in an in vivo model. The study results suggested that the leaves had strong anti-depressant and hypnotic CNS properties that might be exploited for neuropharmacological adjuvant therapy in conventional medicine. However, pharmacological studies are warranted to explore the active substances and the mode of action.

کلیدواژه ها:

Chassalia curviflora ، Gamma-aminobutyric acid ، latent period ، Locomotor behavior ، Neuropharmacological potential