Effect of green tea on inflammation and oxidative stress in cisplatin-induced experimental liver function

Introduction: Cisplatin is one of the most potent chemotherapeutic antitumor drugs. Also, oxidative stress has been established to be involved in cisplatin-induced toxicity. Therefore, the present study was undertaken to examine the antioxidant and anti-inflammation potential of green tea hydroalcoholic extract (GTE) against the liver function of cisplatin in male rats.Methods: Adult male Wistar rats (۱۸۰–۲۵۰ g) were divided into ۴ groups (n = ۵) treated as follows: (۱) control group (saline solution, ۱ ml kg−۱ body weight, i.p.), cisplatin group (۷ mg kg−۱ body weight, i.p.). Animals of Groups III received only green tea extract (۳۰ mg/kg/day, by gavage). Group IV was given green tea extract+ cisplatin once daily for ۲۴ hours. Liver function was evidenced in the cisplatin group by the increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). The mechanism of cisplatin induced liver function was considered as being decreased the total antioxidant power (TAP). Systemic inflammation was assessed by tumor necrosis factor-alpha (TNF-α) levels.Results: A decrease in TAP level in cisplatin group was observed compared with control group. GTE administration decreased TNF-α and increased TAP compared to cisplatin group, but showed no significant differences between groups.Conclusion: The results suggested that green tea could ameliorate cisplatin liver function in rats through reduction of oxidative toxic stress and inflammation.