Comparison of the Diagnostic Accuracy of Serological and Histology Tests for Helicobacter Pylori in Patients with Dyspepsia and Metabolic Syndrome

Background: Helicobacter pylori (H. pylori) infection is a major cause of chronic gastritis, especially in metabolic syndrome patients. The use of a accessible and easy diagnostic method, can speed up the treatment of this infection This study compared two methods of histology and serology for diagnosis of H. pylori in metabolic syndrome patients.Methods: This study was done on ۱۷۵ metabolic syndrome patients with dyspepsia referred to Shahroud Imam Hossain hospital in ۲۰۱۴. From each patient, standard biopsy and serology tests were taken with endoscopy. This data will be analyzed with sensitivity, specificity, positive and negative predictive value.Results: Of the ۱۷۵ patients studied, ۹۰ (۵۱.۴%) were male and ۸۵ (۴۸.۶%) were female. The mean patient age was ۴۶.۹±۱۸.۶ years. From ۱۷۵ patients, ۱۱۴(۶۵.۱%) and ۱۴۹ (۸۵.۳%) patients tested positive by serology and histology, respectively. For the serological test, sensitivity, specificity, positive predictive value and negative predictive value were ۶۶.۴%, ۴۲.۳%, ۸۶.۸%, and ۱۸.۱%. It was also found that with IgG values higher than ۱.۳, there was a sensitivity of ۹۰.۷%, and specificity of ۷۲.۸%, which was considered a positive test. The cut-off point performance test means that maximum at this point with ۷۸.۳% the area under the curve (AUC), there is the highest sensitivity and specificity.Conclusions: Due to the relative sensitivity and specificity of serological tests in comparison with other diagnostic methods as well as the simplicity, speed, and low cost, it is recommended that this test be used for screening metabolic syndrome patients.Background: Helicobacter pylori (H. pylori) infection is a major cause of chronic gastritis, especially in metabolic syndrome patients. The use of a accessible and easy diagnostic method, can speed up the treatment of this infection This study compared two methods of histology and serology for diagnosis of H. pylori in metabolic syndrome patients. Methods: This study was done on ۱۷۵ metabolic syndrome patients with dyspepsia referred to Shahroud Imam Hossain hospital in ۲۰۱۴. From each patient, standard biopsy and serology tests were taken with endoscopy. This data will be analyzed with sensitivity, specificity, positive and negative predictive value. Results: Of the ۱۷۵ patients studied, ۹۰ (۵۱.۴%) were male and ۸۵ (۴۸.۶%) were female. The mean patient age was ۴۶.۹±۱۸.۶ years. From ۱۷۵ patients, ۱۱۴(۶۵.۱%) and ۱۴۹ (۸۵.۳%) patients tested positive by serology and histology, respectively. For the serological test, sensitivity, specificity, positive predictive value and negative predictive value were ۶۶.۴%, ۴۲.۳%, ۸۶.۸%, and ۱۸.۱%. It was also found that with IgG values higher than ۱.۳, there was a sensitivity of ۹۰.۷%, and specificity of ۷۲.۸%, which was considered a positive test. The cut-off point performance test means that maximum at this point with ۷۸.۳% the area under the curve (AUC), there is the highest sensitivity and specificity. Conclusions: Due to the relative sensitivity and specificity of serological tests in comparison with other diagnostic methods as well as the simplicity, speed, and low cost, it is recommended that this test be used for screening metabolic syndrome patients.

کلیدواژه ها:

Helicobacter pylori ، Metabolic syndrome ، Serology ، Histology.