Yeast surface display: An updated insight into the recent applications and technology developments

BACKGROUND AND ABJECTIVEYeast surface display has emerged as a powerful technology for the presentation of diverse biomolecules on the surface of yeast cells. In recent years, this versatile platform has witnessed significant advancements and found applications in various scientific disciplines.MATERIALS AND METHODSPubMed, Web of Science, Scopus, and Google Scholar databases were used to study trends in yeast display and its applications. The review included approximately ۵۰ relevant articles obtained using keywords like "yeast display" and "yeast surface display." We explore the utility of yeast surface display in protein engineering, antibody discovery, enzyme optimization, therapeutics development and biosensor construction. Moreover, we highlight the recent progress made in display methodologies, including the utilization of different yeast species, diverse display systems, and optimization strategies since ۲۰۱۹. The review also delves into emerging trends such as multi-gene display, library screening approaches, and the integration of synthetic biology tools with yeast surface display.RESULTS AND DISCUSSIONThe presented overview emphasizes the growing significance of yeast surface display as a valuable platform for protein engineering and functional characterization. It underscores the potential for innovative applications in diverse research and industrial contexts, marking yeast surface display as a pivotal technology in the advancement of scientific knowledge and biotechnological development.CONCLUSIONThis review provides an updated and comprehensive insight into the recent developments and applications of yeast surface display.

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