Evaluating the effect of a novel ionic liquid ([prolinium chloride] [۱-methylimidazolium ۳-sulfonate]) on a candida albicans standard strain and its cytotoxicity to mammalian cells

Candida albicans (C. albicans) is responsible for most invasive fungal diseases and colonized on the skin and mucosal membranes. The fungus is a part of human natural microflora. Recently, increasing the resistant strains of C. albicans led the researchers to search for new drugs in treatment of candidiasis. The aim of this paper was to investigate the antifungal activity of ([prolinium chloride] [۱-methylimidazolium ۳-sulfonate]) on a candida albicans standard strain. To reach this purpose, minimum inhibitory concentration (MIC) were performed via micro dilution methods. Then to understand the toxicity of the IL, MTT test was done. The obtained data showed that the IL can inhibit C. albicans growth at the ۱۶۹۰ mg/ml concentration (P<۰.۰۰۰۱). Also the IL showed low toxicity to mammalian cells at the same concentration (P<۰.۰۰۵). Our results showed that the IL [prolinium chloride] [۱-methylimidazolium ۳-sulfonate] has a good antifungal activity with low cytotoxicity that may be a good candidate for new drugs designing.

کلیدواژه ها:

C. albicans ، Ionic liquids ، candidiasis ، Toxicity ، mammalian cells