Determintion of the acute and persistant effects of Aluminium on memory and learning Abilities of rat

In regard to the role of Aluminium in the emergence of psychological disorded in patients with chronic kidney diseases,this research project studied the acute,and chronic effects of Alluminium on different stages of memory and learning abilitis,after grouping the rats Alluminium chloride with concentrations of ۱mg,۵mg,۱۰mg and ۲۰ mg was used per kg of body weight.the Alluminium was given by intraperitioeal injection during ۳ phases of ۳۰ days,۶۰ days and ۹۰ days and following this a shuttle box was used to evalute its effects on memory and learning abilities.the results bindicated that plasma level of  Alluminium was significantly increaced,however Alluminium at ۹۰ mg/kg had ni significant effect on the rats ability of learning.however doeses of ۱,۵,۱۰ mg/kg clearly had a significant inhibitory effect on memory and learning Abilities.tyhis inhibitory effect had a direct correlation with the duration and dose of the Alluminium injection.the highest inhibitory effect on memory and learning abilitis was achieved at ۱۵mg/kg dose at ۳۰ and ۴۰ days,which was ۳۴.۵ and ۵۲.۳% respectively (p<۰.۰۵)..injection of ۲mg/kg of arecholine caused an increase of ۲۵% in learning abilitis and was statistically  significant in comparison to the cotrol group(p<۰.۰۵).it can be concluded from this study that Alluminium have an inhibitory effect on metabolism of never cells,and induces alterations on memort level and rat,s learning ability.these change completly depended on the concertration and duration of exposure to Alluminium

کلیدواژه ها:

AL۳+ ، Memory ، learning EEG ، Rat