Serum Levels of Tripartite Motif-containing Protein ۷۲ (TRIM۷۲) in Iraqi Rheumatoid Arthritis Patients and Its Relevance to the Disease Activity State

Background and Objective: Uncontrolled active rheumatoid arthritis patients have a progressive disability, pain, swelling problems, and stiffness that often lead to systemic complications, early death, socioeconomic costs, and comorbidity. The objectives of this study were to measure the serum levels of Tripartite motif-containing protein ۷۲ in Iraqi patients with rheumatoid arthritis and healthy individuals, assessment of the efficiency of Tripartite motif-containing protein ۷۲, determine their essential serum rates in association with disease activity,  sociodemographic and clinical specifications of the diseases. Materials and Methods: In this case-control study, ۱۱۷ Iraqi patients with rheumatoid arthritis were investigated according to the ۲۰۱۰ American College of Rheumatology / European League Against Rheumatism from December ۲۰۲۰ to March ۲۰۲۲. The patients were divided into two groups. Group ۱ were the RA patients with active disease, Group ۲ were the RA patients with inactive disease, and healthy subjects served as the control group. Results: Serum levels of Tripartite motif-containing protein ۷۲ in the active RA groups (۱۰۱.۹۲±۱۶۰.۱۸ Pg/mL) were significantly higher as compared with the inactive RA group (۶۴.۵۸±۵۴.۳۴ Pg/mL) and the control group (۴۱.۰۶ ±۳۲.۴۸ Pg/mL) (P˂۰.۰۰۵). Tripartite motif-containing protein ۷۲ could not discriminate between RA and the controls (since its AUC ≥۰.۶۸۹). Conclusion: There was a positive relationship between DAS-۲۸ESR and Tripartite motif-containing protein ۷۲ levels, which induces bone erosion. The serum Tripartite motif-containing protein ۷۲ level showed a significant elevation in rheumatoid arthritis patients compared with healthy controls. Tripartite motif-containing protein ۷۲ had a poor discriminative ability between RA and the control group.

کلیدواژه ها:

Disease Activity Score ۲۸ ، Rheumatoid Arthritis ، Tripartite Motif-containing Protein ۷۲