Reduction of serum cholesterol in hypercholesterolemic rats by Guar gum
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 1، شماره: 1
سال انتشار: 1390
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 519
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شناسه ملی سند علمی:
JR_AJP-1-1_006
تاریخ نمایه سازی: 1 مهر 1398
چکیده مقاله:
Objective: Several diseases are reported to be uncommon in those parts of the world where dietary fiber intakes are high, therefore, in this study; we evaluated the hypocholesterolemiceffects of a dietary fiber (guar gum) in hypercholesteromic rats.
Materials and Methods: Rats were fed high-fat or a normal fed diet for 12-week then treated with 5% guar gum in their regime during a 28 days period.
Results: Total cholesterol was significantly increased in high-fat diet rats, while administration of guar gum significantly lowered it. Body weight was significantly increased in high-fat diet rats while, at the end of 4-weeks treatment of guar gum, body weight of treated rats was significantly decreased.
Conclusion: These results suggested that guar gum may be effective as hypocholesterolemic agent and may prevent hypercholesteromia in hypercholesteromic rats. The results also suggested that guar gum may be important for reducing body weight in hyperlipidemic rats.
کلیدواژه ها:
نویسندگان
Saeed Samarghandian
Department of Physiology, School of Medicine, Mashhad University Medical Sciences, Mashhad, I. R. Iran
Mosa-Al-Reza Hadjzadeh
Department of Physiology, School of Medicine, Mashhad University Medical Sciences, Mashhad, I. R. Iran
Atiyeh Sadat Davari
Department of Physiology, School of Medicine, Mashhad University Medical Sciences, Mashhad, I. R. Iran
Marziyeh Abachi
Department of Biology, School of Sciences, Islamic Azad University, Mashhad Branch, I. R. Iran