Isolation and determination of Duloxetine using Fe3O4@SiO2 Core-shell Sorbent Followed by the High-performance Liquid Chromatography
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 443
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شناسه ملی سند علمی:
WEECONF01_087
تاریخ نمایه سازی: 18 فروردین 1399
چکیده مقاله:
In this work, a sustainable sorbent called as Fe3O4@SiO2 core-shell was fabricated and applied for enrichment and determination of duloxetine by means of magnetic solid phase extraction (MSPE) followed by high-performance liquid chromatography (HPLC). The factors influencing the extraction performance including pH of sample media, amount of extractor, time and salt amount of sample were investigated and optimized. The standard calibration curve showed linearity range in the concentration level of 15-500 ng mL-1 with r2 of 0.991. Limits of detection (LOD, S/No = 3) and quantification (LOQ, S/N = 10) were 2.5 and 15 ng mL-1, respectively.
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نویسندگان
Kourosh Motevalli
Applied Chemistry Department, Fundamental Sciences Faculty, Islamic Azad University, South Tehran Branch, Tehran ,Iran
Mohsen Zeeb
Applied Chemistry Department, Fundamental Sciences Faculty, Islamic Azad University, South Tehran Branch, Tehran ,Iran
Zahra Yaghoubi
IT Department, Technical& Engineering Faculty, Islamic Azad University, South Tehran Branch, Tehran, Iran