Annexin A1: as novel biomarkers for screening, diagnosis, and monitoring of female reproductive system cancer

Female reproductive system cancer is among the most common malignancies and the primary causes of cancer-related death in women worldwide. The clinical outcome of patients has a close relationship to early and accurate diagnosis of reproductive system carcinoma. Annexin A1 (ANXA1) known as an anti-inflammatory factor which plays a critical role in the proliferation, apoptosis, differentiation, angiogenesis, and metastasis. Previous studies suggested ANXA1 N-terminal peptide Ac2-26 as an anti- proliferation agent in cervical cancer cells by activating the MAPK cascade and targeting p53. Little is known about the clinical significance and diagnosis potential of Annexin A1 as biomarker to diagnosis of the female reproductive system cancer. The present paper aims to provide an overview of the research surrounding the ANXA1 potential as a therapeutic and diagnostic factor and its mechanism of action in female reproductive system cancer.

کلیدواژه ها:

Female ، Biomarkers ، Annexin A1 ، reproductive system cancer ، Peptides