Assessment of Anti-Diabetic, Anti-Atherosclerotic and Antioxidant Effects of Combined Lemon and Garlic Extract in Diabetic Rats Fed with High Cholesterol Diet
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 228
فایل این مقاله در 14 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ZUMS-24-105_006
تاریخ نمایه سازی: 11 اردیبهشت 1400
چکیده مقاله:
Background and Objective: Previous studies have distinctly illustrated the decreasing effects of lemon and garlic extracts on blood glucose and cholesterol. In the present study, the anti-diabetic, anti-atherosclerotic and antioxidant effects of combined lemon and garlic extract were evaluated in diabetic rats fed with high cholesterol diet.
Materials and Methods: The experiment was performed in five groups of rats (N=۴۰); control, diabetic, diabetic plus high-cholesterol, diabetic plus extract and diabetic plus high-cholesterol plus extract. Diabetes was induced by an intravenous injection of streptozotocin (۳۷mg/kg). High-cholesterol diet was prepared by adding ۴% cholesterol and ۱% colic acid to standard food. Treated groups received lemon and garlic extract orally (۱ml, twice a day) for ۶۰ days. At the end, the heart malondialdehyde (MDA) and histopathological changes of aorta were assessed.
Results: Blood glucose significantly increased in diabetic groups (>۲۰۰mg/dl) and blood cholesterol significantly increased in diabetic plus high-cholesterol rats (۱۸۷±۱۵mg/dl). Combined extract significantly decreased the blood glucose of diabetic plus extract group (۱۴۷±۷mg/dl) compared to diabetic group (P<۰.۰۵). Also, this extract meaningfully decreased the blood cholesterol of diabetic plus high-cholesterol plus extract group (۱۰۲±۱۰mg/dl) compared to diabetic plus high-cholesterol group (P<۰.۰۵). The MDA content of the heart were high in diabetic and diabetic plus high-cholesterol groups plus combined extract decreased the level of MDA in both treated groups. Finally, damage to aorta and atherosclerosis was only observed in diabetic& high- cholesterol group.
Conclusion: Based on our findings, combined extract of lemon and garlic was able to prevent atherosclerosis formation and damage of aorta probably by reduction of tissue oxidative stress, blood glucose and cholesterol in diabetic rats fed with high cholesterol diet.
کلیدواژه ها:
نویسندگان
راضیه صاحب نظر
Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
الهام رضازاده
Dept.of Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
همایون صدرایی
Dept. of Anatomy, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
محمدتقی محمدی
Dept. of Physiology and Biophysics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :