Vitamin D Receptor genes polymorphisms (BsmI and TaqI ) and susceptibility to pulmonary tuberculosis in world population (۲۰۱۰-۲۰۲۰): a meta-analysis and systematic review

Background and Aim : Tuberculosis still remains an important cause of morbidity and mortality worldwide. A polymorphism in the vitamin D receptor gene may contribute to susceptibility to tuberculosis. Proper activity of vitamin D receptor on macrophage nuclei as one of the main components of innate host immunity against Mycobacterium tuberculosis. In this study, in the form of a systematic review and meta-analysis, we investigated the frequency of vitamin D, TaqI, and BsmI receptor genes in people with tuberculosis in the world population.Methods : The full texts of English and Persian articles related with these subjects from ۲۰۱۰ to ۲۰۲۰ were included. Review articles, abstracts, articles in languages other than English and Persian, articles with unknown sample locations were excluded. Data were analyzed using meta-analysis and random effects models with the software package Meta R, Version ۲.۱۳ (p <۰.۰۰۰۱) (confidence interval: ۹۵%). Results : The frequency of BB, Bb and bb genotypes in patients with tuberculosis were ۲۹%, ۳۹%, ۳۸% and the frequency of TT, Tt and tt genotypes in patients with tuberculosis were ۶۲%, ۳۰% and ۸%, respectively.Conclusion : In this study, a significant relationship was observed between the genotypic frequency of TaqI and BsmI in VDRL gene in patients with tuberculosis.

کلیدواژه ها:

Vitamin D Receptor gene ، polymorphisms ، pulmonary tuberculosis