BACKGROUND: Doppler echocardiography has been proposed as an appropriate non-invasiveassay to estimate left ventricular end diastolic pressure (LVEDP). The aim of present researchwas to estimate the LVEDP in patients with ischemic heart disease by echocardiography andcompare it with the results of cardiac catheterisation and to determine the effect of differentechocardiographic variables on its measurement.METHODS: In this descriptive-analytic study, patients with diagnosed ischemic heart diseasewere selected by nonrandomized sampling method. Selected population underwent M-modeand pulse doppler echocardiographic evaluation and parameters such as Q-Mitral valve E(Q-MVE), Q-Aortic valve closure (Q-AVC), Aortic valve closure-E (AVC-E), Q-Mitral valveclosure/Aortic valve closure-E (Q-MVC/AVC-E), left ventricle-deceleration time (LV-DT), peakvelocity-deceleration time (PV-DT) and A/E velocity time integral (A/E VTI) were evaluated.Immediately after echocardiography all patients underwent left heart catheterization for LVEDPmeasurement. The relation between different echocardiographic measurements and LVEDP,obtained by cardiac catheterization, was evaluated.RESULTS: In this study, ۴۷ patients with ischemic heart disease with mean age (±SD) of۵۳ ± ۱۳ were studied. There was a significant correlation between LVDEP and A/E VTI (r=۰.۴۴,P = ۰.۰۰۱, and also between LVEDP and PV-DT in patients with A/E VTI ≥۱.۱(r = -۰.۵۸, P = ۰.۰۲).There was a significant correlation between LVEDP and Q-MVC/AVC-E in patients with LVEDP>۱۸mmHg (r = ۰.۷۶, P= ۰.۰۳) and those with LVEDP ≤۱۸ mmHg and A/E VTI < ۱.۱(r = ۰.۳۷, P= ۰.۰۳). The correlation between LVEDP and A/E VTI was more significant in men,in patients aged > ۵۰ years with EF > ۵۵%, without LVH, without MR and those with coronaryartery disease (P < ۰.۰۵).CONCLUSION: Some echocardiographic indices such as A/E VTI, Q-MVC/AVC-E and PV-DTare able to measure LVEDP especially in male patients aged > ۵۰ years, without LVH, withoutMR and those with coronary artery disease but it is necessary to determine specific conditionsand factors affecting these indices, by further studies.Keywords: LVEDP, Coronary Artery Disease, Echocardiography.