Anticancer Effects of Caffeic Acid on A۵۴۹ Non-small CellLung Cancer Cells

Background and Aim : Cancer is a major threat to human health and a global problem, and lungcancer is the most common type of malignant tumor. Caffeic acid is one of the known phenoliccompounds. The beneficial effects of Caffeic acid, including its anti-inflammatory, anti-viral,immune-boosting, antioxidant and carcinostatic and anticarcinogenic properties have beenconfirmed in several studies. The aim of this study was to evaluate the induction of apoptosis inlung cancer cells by Caffeic acid (obtained from propolis).Methods : Cultured lung cancer cell lines (A۵۴۹) were treated with Caffeic acid then the treatedcells were examined by flow cytometry after preparation.Results : The results showed that Caffeic acid has effective roles in inducing apoptosis and hascaused significant changes in the percentage of living cells and the percentage of cells in the earlyand late phase of apoptosis.Conclusion : Caffeic acid has significant apoptotic effects on lung epithelial cancer cells and hasan effective role in inhibiting lung cancer cells, so it can be considered as an effective substancein the treatment of cancer.

کلیدواژه ها:

A۵۴۹ ، Apoptosis ، Caffeic Acid Phenethyl Ester ، Flow cytometry ، Lung Cancer