Circulating nesfatin-۱ levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in females. Nesfatin-۱ is a neuropeptide synthesized in the hypothalamus and other peripheral organs, and there are conflicting opinions about its correlation with PCOS. Objective: This study aims to investigate the correlation between nesfatin-۱ and PCOS and evaluates the effectiveness of nesfatin-۱ as a biomarker for the detection of PCOS in women. Materials and Methods: A systematic review and meta-analysis were conducted to identify pertinent articles from databases such as PubMed, Web of Science, Cochrane, EMBASE, Scopus, and Google Scholar. The standardized mean difference (SMD) and ۹۵% confidence interval (CI) were calculated using a random effects model to compare group outcomes. Additionally, meta-regression and subgroup analysis were performed to elucidate sources of heterogeneity. Results: The meta-analysis involved ۱۲ studies with ۱۲۲۲ participants, and the findings revealed a significant relationship between PCOS and nesfatin-۱ levels. The pooled (SMD = ۰.۵۴; ۹۵% CI: ۰.۰۰-۱.۰۷; p = ۰.۰۴) indicated a significant difference between the evaluated groups. Moreover, a subgroup analysis showed that there was a substantial difference in nesfatin-۱ levels among women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = ۱.۴۶; ۹۵% CI: ۰.۹۲-۲.۰۰; p < ۰.۰۰۱). Conclusion: Our meta-analysis indicates an association between high nesfatin-۱ levels and PCOS. This suggests a potential role of nesfatin-۱ in the development of PCOS and proposes it as a potential diagnostic biomarker for the disease. However, further research is necessary to validate these findings.

کلیدواژه ها:

Polycystic ovary syndrome ، Insulin resistance ، Body mass index ، Meta-analysis. ، سندرم تخمدان پلی­کیستیک ، مقاومت به انسولین ، شاخص توده بدنی ، متاآنالیز.