Restraint of VP۱ Protein of Foot and Mouth Disease Virus using Specific Antiviral Peptides: an in Silico Investigation

Foot and mouth diseases are among the important threats in the animal husbandry industry which lead to huge economic losses. In this regard, the current project aimed to inhibit the VP۱ protein of foot and mouth disease viruses using specific peptides. For this purpose, a wide range of potential antiviral peptides were collected from the database. Physicochemical properties, hydrophobicity/hydrophilicity, and solubility properties of potential antiviral peptides were investigated using reliable servers. Afterward, the tertiary structures of the selected peptides along with the VP۱ protein were modeled by the I-TASSER server. Moreover, interactions between VP۱ protein and selected antiviral peptides were investigated using the ClusPro ۲.۰ server. Finally, the outputs of molecular docking were assessed by LigPlot+ and visualized by PyMol software. The results revealed that Dermaseptin-۳, Ginkbilobin, Circulin-F, Maximin۱, Cycloviolin-A, Cycloviolin-D, Circulin-C, Cycloviolin-C, and Antihypertensive protein BDS-۱ peptides with a hydrophobicity value of > ۳۰ were soluble with positive instability index and positive net charge. Moreover, the results of the molecular docking process demonstrated that Dermaseptin-۳ and Ginkbilobin peptides could strongly inhibit the VP۱ protein using ۱۰ hydrogen bonds. Therefore, these two peptides, which had the most hydrogen bonds, were introduced as the best anti-foot and mouth disease virus peptides to apply.

کلیدواژه ها:

Antimicrobial Peptide ، Foot and Mouth disease ، In silico ، VP۱