Improving the dissolution properties of spironolactone using liquisolid technique
محل انتشار: مجله تحقیقات دارویی و بیومدیک، دوره: 1، شماره: 3
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 92
فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_PBRE-1-3_007
تاریخ نمایه سازی: 10 دی 1402
چکیده مقاله:
In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol ۴۰۰ and glycerin). The ratio of microcrystalline cellulose (as carrier) to silica (as coating powder material) was ۲۰ for all formulations. After preparing tablets by direct compression with constant compression load, the release profiles were evaluated by USP paddle method. Differential scanning calorimeter (DSC) and FTIR were used to evaluate any interaction between spironolactone and other ingredients. The liquisolid tablets exhibited significantly higher dissolution rates in comparison with conventionally direct compressed tablets. Furthermore results showed dissolution rate enhancement of liquisolid tablets by increase in the amounts of non-volatile vehicles. Differential scanning calorimetry showed that, the drug has got solubilized in the liquid vehicle. FT-IR spectroscopy studies of pure spironolactone, liquisolid compacts, glycerin and PEG۴۰۰ supported solubilization of the drug in the liquid vehicle too. The FT-IR spectra also showed that no interactions have been occurred between spironolactone and other ingredients. In conclusion the liquisolid technique can be a suitable method in order to prepare rapid release tablets of poorly water-soluble drugs such as spironolactone.
کلیدواژه ها:
نویسندگان
Jafar Akbari
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Majid Saeedi
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Katayoun Morteza-Semnani
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Zaynab Sadeghi Ghadi
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Seyed Saeed Hosseini
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :