Efficacy of vaginal misoprostol and vaginal washing with ۳% acetic acid for first trimester pregnancy termination: A randomized single blind clinical trial

Introduction: This study was conducted to evaluate the efficacy of ۸۰۰μg vaginal misoprostol after wetting alkaline PH vagina with ۳% acetic acid in comparison with ۸۰۰μg vaginal misoprostol alone in the alkaline PH vagina in terminating first trimester pregnancies. Methods: In this clinical trial, a total of ۱۰۰ healthy women between ۲۰ and ۴۰ years old requesting legal termination of pregnancy before ۱۲ weeks gestation (۹۸ missed cases ۵۰ in group A and ۴۸ in group B and ۲ fetus with great anomaly in group B) were randomly assigned to either of the treatment groups to receive ۸۰۰μg vaginal misoprostol after wetting vagina with three pieces of cotton soaked in ۳ml of ۳% acetic acid or ۸۰۰μg vaginal misoprostol alone for induction abortion. Pregnant women with active vaginal bleeding, rupture of membrane, coagulopathy, corticosteroid consumption, previous cesarean section and any contraindication of misoprostol using were excluded. Duration of extraction or expulsion of the pregnancy product, complications, and treatment failure were collected. Data was analyzed using SPSS ۱۹ by descriptive statistics and statistical tests comprising independent t-test and chi-square. Results: Totally ۱۴ patients had complete abortion (۷ subjects in each group) and ۸۶ had incomplete abortion (۴۳ patients in each group). The success rate was not significantly different between both groups. The overall median induction-abortion interval was ۱۹±۱۴ hour. Conclusion: Vaginal misoprostol in alkaline PH vagina wetted with ۳% acetic acid was not significantly more effective than vaginal misoprostol alone in alkaline PH vagina in first trimester pregnancies.

کلیدواژه ها:

Pregnancy Trimester First ، Misoprostol ، Acetic Acid ، Pregnancy Trimester First ، Misoprostol ، Acetic Acid