Role or monoclonal antibody and abc transporters in cancer
محل انتشار: سومین سمپوزیوم بین المللی سرطان نسترن
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 470
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شناسه ملی سند علمی:
NASTARANCANSER03_016
تاریخ نمایه سازی: 7 اسفند 1396
چکیده مقاله:
CSCs are responsible for high rate of recurrence and Chemoresistance of different types of cancer. The expression of ATP-binding Cassette (ABC) transporters family and the activation of different signalingpathways .For example( Wnt/β-catenin signaling ,Hedgehog,Notch,Akt/PKB) are reported .Considering ABC transporters expression on CSCs membranes compounds able to modulate MDR could induce cytotoxicity in these cells disclosing an exciting and alternative strategy for targeting in tumor therapy .Targeting CSCs could be a strategy to improve the outcome of cancer therapy but this is not as simple as it seems. Target such as CD۱۳۳ and EPCAM/ESA could mark out CSCs from normal cells. Monoclonal antibodies are clinically and commercially established therapeutics. This review aims to examine the biology of cancer Stemcells considering the markers defining them and their survival and will describe the new antibody-focused strategies emerging to target them for more effective treatment of cancer
کلیدواژه ها:
نویسندگان
Ashkan Abbasi Fard Semnani
Department Of Microbial Biotechnology,Semnan National University Of Iran
Fatemeh Tabei
Department Of Pharmacy ,Islamic Azad University Of Damghan
Milad Heydarhaei
Department Of Biology,Islamic Azad University Of Damghan
Amirhossein Mohammadzade
Department Of Biology,Islamic Azad University Of Damghan