Oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of male adolescent mice after acute exposure
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 17، شماره: 7
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 129
فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-17-7_009
تاریخ نمایه سازی: 4 آبان 1400
چکیده مقاله:
Objective(s):The present study was undertaken to determine the effects of acute exposure to malathion on oxidative stress and cytotoxic potential of anticholinesterase insecticide, malathion in reproductive toxicology of adolescent male mice. Materials and Methods: Thirty two adolescent male mice at pubertal age were treated with ۵۰۰ mg/kg body weight (BW) of malathion for three days. After exposure, biochemical markers and sperm analysis were evaluated and finally histological modifications of testis and sperm were assessed. Results: Our data showed that treatment of male mice with malathion (۵۰۰ mg/kg, BW) could lead to oxidative stress. Induced oxidative stress status can be assessed due to increased malondialdhyde (MDA) content, decreased thiol group content, as well as increased antioxidant enzyme activities. On the other hand, exposure to malathion at the pubertal age led to alteration of semen parameters; sperm production and percentage of motile sperm were decreased in the treated groups compared to the control. Furthermore, exposure of male mice to malathion led to a decrease of testosterone level, inhibition of acetylcholinesterase, and decrease of the reproductive performance of male mice after three days of treatment at the age of puberty. Conclusion: The importance to carry out in vitro reproductive toxicology assays lies on the need of knowing the alterations these insecticides may cause at cellular level, since they are endocrine disruptors that interfere with reproductive functions.
کلیدواژه ها:
نویسندگان
Selmi Slimen
Laboratory of Animal Physiology, Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia
El Fazaa Saloua
Laboratory of Animal Physiology, Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia
Gharbi Najoua
Laboratory of Animal Physiology, Department of Biology, Faculty of Sciences, University Tunis El Manar, Tunis, Tunisia
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :