Survival Rate of Colorectal Cancer in Eastern Mediterranean Region Countries: A Systematic Review and Meta-Analysis

Introduction: Colorectal cancer is the second most common cause of cancer-related deaths worldwide. Survival rates are among the most important factors in quality control and assessment of treatment protocols. This study was aimed to assess the survival rate of colorectal cancer in Eastern Mediterranean Region Countries. Methods: The present study was a systematic review and meta-analysis. We comprehensively searched ۶ international databases including PubMed/Medline, ProQuest, Scopus, Embase, Web of Knowledge and Google Scholar for published articles until November ۲۰۱۸. Among the total of ۱۰۲۳ titles found in the systematic search, ۴۳ studies were eligible to be included in the present meta-analysis. The Newcastle-Ottawa Quality Assessment Form for Cohort Studies was applied to evaluate the quality of included studies. The heterogeneity of papers was assessed with the Cochran Test and I-Square statistics. Results: According to the results, the ۱-year, ۳-year and ۵-year survival rate of patients with Colorectal Cancer was ۸۸.۰۷% (۹۵% CI, ۸۳.۲۲-۹۲.۹۲), ۷۰.۶۷% (۹۵% CI, ۶۶.۴۰-۷۴.۹۳) and, ۵۷.۲۶% (۹۵% CI, ۵۰.۴۳-۶۴.۱۰); respectively. Furthermore, Meta-regressions did not show significant correlations between survival rate and year, sample size or Human Development Index. Conclusion: Documented and comprehensive evidence-based findings of the present meta-analysis can be used to enhance policies and outcomes of different medical areas including prophylaxis, treatment and health related objectives in colorectal cancer.

کلیدواژه ها:

Neoplasm ، colorectal cancer ، Survival