Semi-competing risks survival modeling: Predicting early recurrence and death after curative resection in patients with colorectal cancer

Introduction: Survival modeling in the presence of semi-competing risks in predicting early recurrence and death after curative surgery in patients with colorectal cancer Methods: This study is a retrospective cohort of ۲۸۴ patients with colorectal cancer who underwent surgery referred to Imam Khomeini Clinic in Hamadan during the years ۱۳۸۰-۱۳۹۶. All demographic information and other required information were extracted from patients' records. The age at the time of diagnosis, sex and clinical and pathological variables, type and date of first treatment, degree of tumor differentiation, disease stage, recurrence and metastasis, types of treatment (surgery, chemotherapy and radiotherapy) were included as the predictors. The Survival modeling was performed in the presence of semi-competing hazards in R ۴.۱ software to analyze the data. Results: The results showed that for nonterminal event of recurrence metastasis to other organs, age, stage of disease was significantly related. Also, for terminal event of death, age, stage of disease, and chemotherapy was the significant predictors. Conclusion: Suitable and tailored steps could be taken for policy making according to the specific results obtained for terminal and nonterminal events.

کلیدواژه ها:

recurrence ، death ، colorectal cancer ، Semi-competing risks survival modeling