The relationships between Galectin-۳ levels with cardiac structure and function in well- trained endurance athletes

Introduction: Clinical studies support a potential role of galectin-۳ in the pathogenesis of remodelling in heart failure in humans; but these relationships in athletes are not well known. The present study was conducted to examine the relationships between galectin-۳ levels with cardiac structure and function in well-trained endurance athletes. Material & Methods: Fifteen well-trained endurance male athletes (aged: ۲۱.۴ ± ۳.۰ years; mean ± SD) volunteered to participate in this study. Galectin-۳ concentrations were assessed by enzyme-linked immunosorbent assay (ELISA) kits and cardiac morphology and function were assessed by echocardiography. Pearson correlation test was used to analyze the relationship between the variables. Results: The results demonstrated that galectin-۳ concentrations positively related to aorta diameter (r = ۰.۶۱, P = ۰.۰۱) and negatively related to left ventricle end-diastolic volume (LVEDV) (r = ‒ ۰.۶, P = ۰.۰۱). No significant relationships were observed between galectin-۳ concentrations with left ventricle ejection fraction (LVEF) (r= ‒ ۰.۰۸, P = ۰.۷), pulmonary artery diameter (r = ۰.۲۵, P = ۰.۳), posterior wall thickness of left ventricle at end diastole (PWTLV) (r = ۰.۳۷, P = ۰.۱), interventricular septal (r = ۰.۱۵, P = ۰.۵), and left ventricle end-systolic volume (LVESV) (r = ۰.۴۸, P = ۰.۰۷). Conclusions: In conclusion, galectin-۳ concentrations are associated with echocardiographic markers of ventricular function in endurance athletes.

کلیدواژه ها:

Galectin-۳ ، Cardiac structure ، Cardiac function ، Endurance-trained athletes