A Novel Approach for Study of Surface Morphology & Roughness Analysis for Characterization of Precipitation Product at A Nanoscale Level via the Reaction of Fluconazole with Phosphomolybidic Acid

The purpose of this study is to combine FIA and AFM to explain surface morphology utilizing a newly developed instrument, the NAG-۴SX۳-۳D analyzer. The study is dedicated on a new approach for determining fluconazole drug via reaction with phosphomolybdic acid as a precipitating agent to obtain a sufficient amount of weight (pale yellow precipitate) for the AFM sample and determine through the roughness parameters. The main advantage of the proposed approach lies in its ability in determining number of nanoparticles that can occupy the empty surface area starting from the ۱st ground monolayer calculates the unoccupied surface area and determines the nanoparticles concentration which participated on the surface. Thus, a microfluidic flow system is proposed for continuous synthesis of nanoparticles by chemical reaction of precipitation reagent with the pharmaceutical active ingredients. The flow system allows the nanoparticles synthesis in a smooth manner without clogging. All of the flow injections conditions (physical and chemical) were examined and fixed. The average diameters of drug is ۶۲.۰۲ nm, Grain No. ۳۰۶, Roughness Average ۲.۷۶, peak to peak = ۱۴ nm, ten point height = ۱۳.۹ nm, and surface kurtosis = ۲.۲ for surface area of scanned section with a dimension of ۲۳۶۲۳۶۹ nm۲.

کلیدواژه ها:

Atomic force microscopy ، scanning probe microscope ، Flow injection analysis ، mode of operation