Evaluation of Bioactivity of PHB/nHA Composite Scaffold for Bone Tissue Engineering

this study is based on the synthesizing hydoxyapatite nanoparticles and the technique used for this purpose was sol gel. Salt leaching and solvent casting technique was adapted for the fabrication of Poly 3-hydorxybutyrae/Hydorxyapatite nanoparticles. Synthesized hydroxyapatite nanoparticles, polymer and composite were confirmed by XRD. poly (3-hydroxybutyrate) without nHA and with 5 and 10 wt % of nHA were prepared. The weight percent of NaCl was 90. According to the Scanning electron microscopy (SEM) results, the pore size was 212-250μm and interconnectivity, morphology and distribution of pores in prepared scaffolds were also uniform. The bioactivity of the scaffolds was demonstrated by immersion in simulated body fluid (SBF) for up to 28 days. Formation of hydroxyapatite crystals on the surface of scaffolds was confirmed by SEM and EDXA. This study indicated that the scaffolds with 10 wt%HA had the best bioactivity for bone tissue engineering

کلیدواژه ها:

Bioactivity ، Poly 3-hydroxybutyrate ، NanoHydroxyapatite ، Scaffold ، bone tissue engineering