The Effect of One Period of Endurance Training and Consumption of Hydroalcoholic Extract of Urtica Dioica on Oxidative Stress Indices of Heart Tissue in STZ-Induced Diabetic Rats

Introduction: Oxidative stress plays a key role in the onset and development of diabetes-related complications. Due to the antioxidant effect of exercise and Urtica dioica (UD), this study aimed to evaluate the effect of one period of endurance exercise and hydroalcoholic extract of Urtica dioica on oxidative stress indices of heart tissue in STZ-Induced diabetic rats. Material & Methods: In this study, ۵۰ Wistar rats (mean±SD weight: ۲۳۲.۱۲±۷.۴۲ g) were randomly divided into five groups: Healthy-sedentary, Diabetes-sedentary, Diabetes-Exercise, Diabetes-Urtica dioica, and Diabetes-Exercise-Urtica dioica. Diabetes was induced by intraperitoneal injection of streptozotocin (۴۵ mg/kg) and ۴۸ hours after injection, blood glucose levels above ۳۰۰ mg/dl were the criteria for the confirmation of diabetes. Endurance exercise with moderate intensity (۵ days/week) and daily gavage of hydroalcoholic extract of UD was performed at ۵۰ mg/kg for six weeks. Data were analyzed in SPSS software (version ۲۰) through Shapiro-Wilk, two-way ANOVA, and Tukey post hoc test. Findings: Two weeks after STZ injection, body weight in the Diabetes-Urtica dioica (P=۰.۰۰۱), Diabetes-Exercise (P=۰.۰۳۴), and Diabetes-Exercise-Urtica dioica (P=۰.۰۲۵) groups decreased, compared to the Healthy-sedentary group, and this reduction continued until the end of the sixth week. In addition, six weeks of endurance exercise and UD extract significantly reduced blood glucose concentration in the Diabetes-Exercise (P=۰.۰۰۱), Diabetes-Urtica dioica (P=۰.۰۰۱), and Diabetes-Exercise-Urtica dioica (P=۰.۰۰۱) groups, compared to the Diabetes-sedentary group. Furthermore, endurance training and UD extract caused a significant increase in catalase (P=۰.۰۱۹) and glutathione peroxidase (P=۰.۰۲۸) values and a significant decrease in heart tissue malondialdehyde (P=۰.۰۰۱). Discussion & Conclusion: Six weeks of endurance training combined with UD extract can increase the antioxidant index and decrease lipid peroxidation in the heart tissue of diabetic rats with streptozotocin.

کلیدواژه ها:

Diabetes ، Endurance Exercise ، Heart tissue ، Oxidative stress ، Urtica Dioica ، استرس اکسیداتیو ، بافت قلب ، تمرین استقامتی ، دیابت ، گزنه