Solid/liquid Phase Microextraction of Anticancer Drug Cisplatin by Using a Hollow Fiber Reinforced with Multiwalled Carbon Nanotube- Ion Exchange Polyurethane Foam, and Determination by Graphite Furnace Atomic Absorption Spectrometry

For the first time, hollow fiber-solid liquid phase microextraction (HF-SLPME) using multiwalled carbon nanotube- ion exchange polyurethane foam (MWCNT-PUFIX) as adsorbent along with graphite furnace atomic absorption spectrometry was used to extract and measure the anticancer drug cisplatin. In this method, the nanocomposite dispersed in octanol, is located in the pores and lumen of a porous polypropylene hollow fiber, was used as the extracting phase, this method benefits from high selectivity, high sample purification and enrichment, and reducing the consumption of organic solvents. The major factors affecting the extraction efficiency were investigated. The validation of the method was assessed by linearity, limit of detection, and accuracy calculated as relative recovery percent. The calibration curve was constructed under the optimal conditions was linear in the range of ۱.۰۰-۵۵.۰ µg/mL and the detection limit was ۰.۵ µg/mL. This method was successfully used for analysis of biological samples and the obtained results showed that the method has good accuracy and precision.

کلیدواژه ها:

Multiwalled carbon nanotube ، Ion exchange polyurethane foam ، Cisplatin ، Graphite Furnace Atomic Absorption Spectroscopy