Synthesis and Application of Fe۳O۴@Au Composite Nanoparticles as Magnetic Resonance/Computed Tomography Dual‑Modality Contrast Agent
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 76
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شناسه ملی سند علمی:
JR_JMSI-10-3_007
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Background: None of the molecular imaging modalities can produce imaging with both anatomical
and functional information. In recent years, to overcome these limitations multimodality molecular
imaging or combination of two imaging modalities can provide anatomical and pathological
information. Methods: Magnetic iron oxide nanoparticles were prepared by co‑precipitation
method and then were coated with silica according to Stober method. Consequently, silica‑coated
nanoparticles were amino‑functionalized. Finally, gold nanoparticles assembled onto the surfaces of
the previous product. Cytotoxicity effects of prepared Fe۳O۴@Au nanoparticles were evaluated by
۳‑(۴,۵‑dimethylthiazol‑۲‑yl)‑۲,۵‑diphenyltetrazolium bromide assay on human hepatocellular carcinoma
cells. Their ability as a dual‑mode contrast agent was investigated by magnetic resonance (MR) and
computed tomography (CT) imaging. Results: Fe۳O۴@Au nanoparticles were spherical undersize
of ۷۵ nm. X‑ray diffraction analysis confirmed the formation of Fe۳O۴@Au nanoparticles. The
magnetometry result confirmed the superparamagnetism property of prepared nanoparticles, and the
saturation magnetization (Ms) was found to be ۳۳ emu/g. Fe۳O۴@Au nanoparticles showed good
cytocompatibility up to ۶۰ μg/mL. The results showed that the Fe۳O۴@Au nanoparticles have good r۲
relaxivity (۱۳۵.۲۶ mM−۱s−۱) and good X‑ray attenuation property. Conclusion: These findings represent
that prepared Fe۳O۴@Au nanoparticles in an easy and relatively low‑cost manner have promising
potential as a novel contrast agent for dual‑modality of MR/CT imaging.
کلیدواژه ها:
نویسندگان
Mohammad Reza Keshtkar
Department of Medical Physics and Radiology, Gonabad University of Medical Sciences, Gonabad
Daryoush Shahbazi-Gahrouei
Department of Medical Physics, Isfahan University of Medical Sciences, Isfahan, Iran
Alireza Mahmoudabadi
Department of Medical Physics and Radiology, Gonabad University of Medical Sciences, Gonabad