Effects of Probiotics on Prevalence of Ventilator-Associated Pneumonia in Multitrauma Patients Hospitalized in Neurosurgical Intensive Care Unit: A Randomized Clinical Trial

Background: Probiotics may have a role in preventing ventilator-associated pneumonia (VAP) by inhibiting the natural flora from transforming into pathogenic flora. Objective: Therefore, this study aimed to investigate the effects of probiotics on the prevalence of VAP in multitrauma patients hospitalized in a neurosurgical intensive care unit (ICU). Methods: This randomized clinical trial was performed between ۲۰۱۸ and ۲۰۱۹ with the participation of ۱۵۰ patients hospitalized in theNeurosurgical ICU. After randomizing the participants (using the permutable blocking method) into the intervention (probiotic) and control (placebo) groups, the interventions were implemented. The participants received one capsule every ۱۲ hours by gavage and their VAP symptoms were evaluated and recorded. Data were inputted into SPSS۲۲ and then compared using the chi-square, independent t-test, Fisher's exact tests, and repeated measures ANOVA. Results: The prevalence of VAP was significantly lower in the intervention group than the control group (p=۰.۰۰۱). A significant difference was observed between the two groups in pH (p=۰.۰۲۹) and WBC (p=۰.۰۴۲). The between-group difference was not significant in other variables. Conclusion: Probiotics are effective in reducing the prevalence of VAP in trauma patients hospitalized in ICU.

کلیدواژه ها:

Ventilator-associated pneumonia ، Trauma ، Probiotic ، Lactocare