The Relationship of Cadmium, Nickel, and Manganese Trace Elements with Oxidative Stress in the Semen of Infertile Men
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 63
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شناسه ملی سند علمی:
JR_ZUMS-31-147_008
تاریخ نمایه سازی: 10 آبان 1402
چکیده مقاله:
Background and Objective: Trace element levels are important for sperm function. On the other hand, oxidative stress is one of the most important causes of DNA damage. This study aimed to evaluate the relationship between cadmium (Cd), nickel (Ni), and manganese (Mn) trace elements and also oxidative stress in infertile men.
Materials and Methods: This case-control study was carried out on ۵۰ oligozoospermic, ۵۰ asthenozoospermic, and ۵۰ normozoospermic men. All individuals were subjected to semen analysis. Cadmium, nickel, manganese, total antioxidant capacity (TAC), and total oxidant status (TOS) were detected using the manual assays. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were analyzed using the ELISA.
Results: The findings revealed that there was a significant increase in TOS index in the patient groups compared to the normozoospermic group (p = ۰.۰۴۵, p = ۰.۰۳۸ respectively); however, these changes were downward for the TAC factor. The levels of SOD and GPx activities were significantly reduced in the patient groups compared to the normozoospermic group (p = ۰.۰۱۵, p = ۰.۰۲۰ respectively). Also, Cd and Ni levels were significantly elevated and had a negative association with TAC in the patient groups compared to the normozoospermic group. However, the results of Mn level showed a significantly lower value and a positive association with the TAC index.
Conclusion: Mn as a component of SOD enzyme is necessary for normal sperm functions. In contrast, high levels of Cd and Ni are toxic for human sperm and negatively correlated with TAC and sperm parameters.
کلیدواژه ها:
نویسندگان
Alireza Gharabaghi
School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Sajjad Yavari Bazl
School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Khadijeh Baranizadeh
Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Ali Heshmati
Dept. of Nutritional Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Gholamreza Shafiee
Dept. of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
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