The Mechanism of Action and Potential Impact of Flaxseed on Gastrointestinal Manifestations in Cystic Fibrosis: A Narrative Review
محل انتشار: مجله پزشکی کودکان، دوره: 10، شماره: 1
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 97
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شناسه ملی سند علمی:
JR_JPRE-10-1_004
تاریخ نمایه سازی: 9 آذر 1402
چکیده مقاله:
Background: Cystic fibrosis (CF) is an inherited disease, which leads to death at a young age. No definite treatment has yet been found for CF. Therefore, it is important to find new therapeutic and medicinal approaches for CF. Flaxseed is an antioxidant dietary and anti-inflammatory supplement with a high omega-۳ fatty acid content.
Objectives: In this article, the mechanism of action of flaxseed as a novel supplemental treatment for CF is discussed.
Methods: In this review, we searched Iranian traditional medicine (ITM) sources, such as Zakhire Kharazmshahi and Canon of Medicine. Then, from inception to October ۲۰۲۰, data sources, including Google Scholar and PubMed in the English language were comprehensively explored for the mechanism of action of this herbal remedy on CF.
Results: Flaxseed may possess effects on CF gastrointestinal disorders due to its properties, including consumer acceptance as a functional food, being the best non-animal reservoir of omega ۳ fatty acid, alpha-linolenic acid (ALA), and soluble fiber, as well as its anti-inflammatory and antibacterial effects with modulating intestinal microbiota.
Conclusions: Regarding the mentioned potential mechanisms of action, it could be hypothesized that flaxseed can be served as a novel medicine for CF.
کلیدواژه ها:
نویسندگان
Hanieh Tahermohammadi
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeed Sadr
Department of Pediatrics Pulmonary Diseases, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arian Karimi Rouzbahani
USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran.
Shahpar Kaveh
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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