Evaluation of Humoral Immune Response of Cats to the Experimental Infection with the different Clonal Types of Toxoplasma gondii by Measurement of IgG Antibodies

Toxoplasma gondii is one of the most prevalent parasitic infections in world. Rh, NED and Me۴۹ are of the most prevalent clonal types of the parasite isolated till now. Differences in pathogenicity and virulence of different types have been investigated in different studies. No controlled study was performed to compare the ability of different types to initiate humoral immune response. We investigated IgG antibody responses of kittens infected with each of these three clonal types. For this, experimental infection was performed using ME۴۹ clonal type of T. gondii and humoral immune response (by measurement of IgG) was detected and compared with the other two clonal types of the parasite. No antibodies were detectable at least until ۷ days post infection for types Rh and NED while this period of no response was ۱۹ days for ME۴۹. Serum ELISA indices were significantly higher in kittens infected with Rh and NED tpes in comparison with ME۴۹. The results of this study showed that humoral immune response of cats to ME۴۹ starts with delay and are weaker than two other clonal types.

کلیدواژه ها:

Cats ، Toxoplasma gondii ، NED ، ME۴۹ ، Rh