Clinical and capillaroscopy correlation of Pentraxin ۳ and mean platelet volume in patients with systemic sclerosis: A case control study
محل انتشار: فصلنامه تحقیقات روماتولوژی، دوره: 9، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 67
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شناسه ملی سند علمی:
JR_RHRE-9-1_005
تاریخ نمایه سازی: 14 بهمن 1402
چکیده مقاله:
Systemic sclerosis (SSc) is a systemic connective tissue disease with vasculopathy and tissue fibrosis. Mean platelet volume (MPV) indicates the platelet activation and independent risk factor for arterial diseases. Long pentraxin, or pentraxin-۳ (PTX۳), is a homologous pattern recognition receptor mainly presented in inflammatory diseases with some inhibitory effects on chronic inflammation. This study aimed to evaluate the relationship between clinical and capillaroscopy manifestations of patients with SSc, MPV, and PTX۳ levels compared to the control group. This case-control study was conducted on patients who met the SSc diagnostic criteria. Accordingly, clinical manifestations and capillaroscopy data were recorded. Thus, the MPV and PTX۳ levels of the patients and the control group were checked. Then, the relationship between the clinical and capillaroscopy results was evaluated. The mean ± SD of MPV in the control group and patients was ۱۰.۱۱ ± ۰.۹۶ fL and ۹.۶۵ ± ۱.۱۳ fL, respectively (Pvalue = ۰.۰۴۳). In addition, the PTX۳ level was ۳.۶۰ ± ۸.۹۸ and ۱.۷۹ ± ۵.۷۷ ng/ml, respectively (P-value = ۰.۲۲۳). The relationship of these factors with the clinical and capillaroscopy results was insignificant (P-value > ۰.۰۵). Based on the results, the MPV level was significantly lower in patients with SSc than controls, while the PTX۳ level did not differ between the groups. Moreover, there was no relationship between PTX۳ and MPV levels with the capillaroscopy and clinical results. However, further studies with larger sample sizes are recommended.
کلیدواژه ها:
نویسندگان
Saeedeh Shenavandeh
Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran.
Hosniyeh Nematizadeh
Department of Internal Medicine Shiraz, University of Medical Science, Shiraz, Iran.
Fatemeh Asadian
Department of Pathology, University of Medical Science, Shiraz, Iran
MohammadAli Nazarinia
Department of Internal Medicine, Division of Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran
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