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A Study of Sonodynamic Therapy of Melanoma C۵۴۰ Cells in Vitro by Titania/Gold Nanoparticles

محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 14، شماره: 1
سال انتشار: 1403
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 58

فایل این مقاله در 12 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1905771

شناسه ملی سند علمی:

JR_JBPE-14-1_005

تاریخ نمایه سازی: 21 بهمن 1402

چکیده مقاله:

Background: Sonodynamic Therapy (SDT), a safe and non-invasive strategy in tumor therapy, is in development using novel sono-sensitizers, activated by low-intensity ultrasound radiation. SDT mainly progresses through Reactive Oxygen Species (ROS) generation followed by cell annihilation.Objective: The current study aimed to investigate the effect of ultrasound therapy with titania/gold nanoparticles (NPs) on melanoma cancer.Material and Methods: In this experimental study, Titania/gold NPs (TGNPs) were synthesized, and their activity was investigated in sonodynamic therapy of a melanoma cancer cell line (C۵۴۰). SDT was performed at ۱.۰ W cm-۲ and ۱.۰ MHz for one minute.Results: The synthesized NPs that comprised gold NPs of <۱۰ nm into titania NPs of <۲۰ nm showed great stability and cytocompatibility. While TGNPs were biocompatible, a remarkable rate of cell ablation was observed upon ultrasound irradiation due to ROS generation. Conclusion: The SDT using TGNPs can be introduced as an alternative and low-cost treatment method for melanoma malignancy.

کلیدواژه ها:

Malignant melanoma ، Metal Nanoparticles ، Gold ، Non-Ionizing Radiation ، Reactive Oxygen Species

نویسندگان

Ghazale Perota

Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Parsa Faghani-Eskandarkolaei

Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Niloofar Zahraie

Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Hosein Zare

Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran

Naghmeh Sattarahmady

Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

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