Effect of Citrullus Colocynthis Pulp on Renal Function in Streptozotocin-Induced Diabetic Rats

Introduction: Diabetic nephropathy is one of the most serious microvascular complications of diabetes and the main cause of end-stage renal disease. Various herbs have been used to control diabetes complications. This study aimed at investigating the effect of Citrullus colocynthis pulp on diabetes-induced renal damage in male rats. Methods: A total of ۳۶ rats were divided into ۶ groups: ۱- normal (N), ۲- normal + ۱۰ mg/kg colocynth (N+C۱۰), ۳- normal + ۳۰ mg/kg colocynth (N+C۳۰), ۴- diabetic (D), ۵- diabetic+۱۰ mg/kg colocynth (D+C۱۰), and ۶- diabetic+۳۰ mg/kg colocynth (D+C۳۰). The rats received colocynth pulp through gavage for two weeks. The obtained data were analyzed through ANOVA and Tukey test using SPSS ۱۶. Results: The diabetic rats showed a sharp rise in the volume of urine, clearance of albumin, clearance of creatinine, and serum urea. Administration of colocynth in diabetic rats improved the changes to normal. Conclusion: The results of this study show that colocynth pulp has the potential to treat diabetes and to prevent the relevant kidney damages.

کلیدواژه ها:

Diabetes Mellitus ، Citrullus Colocynthis ، Rat ، Diabetes Mellitus ، Citrullus Colocynthis ، Rat