Synthesis, Spectral and Biological Studies of Co(II), Fe(II), Ni(II), Cu(II), Pd(II), Mn(II), Hg(II), Cd(II), and Zn(II) Complexes Derived from Benzohydrazide Schiff Base

Electronic absorption spectra, infrared spectroscopy, nuclear magnetic resonance, molar conductance, and elemental analysis are some of the physicochemical methods used to characterize the ۴-chloro-N'-[(E)-(۲,۶-dihydroxy phenyl) methylidene] benzohydrazide (HBHDH) molecule that has been synthesized. The results of the analysis show that the metal and ligand formed a ۱:۲ ratio. According to the spectra, the ligand HBHDH forms tridentate coordination spheres with metal ions using an ONO bond. Complexes with Fe(II), Co(II), Ni(II), Cu(II), and Mn(II) have an octahedral shape because of this. In contrast to the tetrahedral structure of the complexes created with Zn(II), Cd(II), and Hg(II), the Pd(II) complex takes on a square planar layout. According to the molar conductance values in DMF, the complexes do not undergo electrolysis. It has been determined that the metal complexes and Schiff's base HBHDH ligand have antibacterial action. The antibacterial efficiency of each combination and ligand against E. coli bacteria is higher than that of regular streptomycin.Candida albicans (MCC ۱۴۳۹) and Saccharomyces cerevisiae (MCC ۱۰۳۳) have significant antifungal effectiveness, with their growth being inhibited by over ۹۲% in the presence of Mn(II) and Fe(II) complexes, respectively.

کلیدواژه ها:

Antimicrobial activity ، ۴-Chlorobenzohydrazide ، ۲ ، ۶-Dihydroxybenzaldehyde ، Octahedral geometry