L-carnosine improves short-term spatial recognition memory and passive avoidance learning and memory in streptozotocin-diabetic rats
محل انتشار: پنجمین کنگره ملی زیست شناسی و علوم طبیعی ایران
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 687
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شناسه ملی سند علمی:
BSCONF05_158
تاریخ نمایه سازی: 22 دی 1396
چکیده مقاله:
Background and Objective: Diabetes mellitus (DM) affects synaptic plasticity in the hippocampus, leading to impairments in learning and memory. L-carnosine, an endogenous dipeptide, is reported to exhibit anti-diabetic and antioxidant effects. Therefore, this study was designed to evaluate its effect on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wistar rats (n=32) were randomly divided into four groups: control, control treated with carnosine (100 mg/kg), diabetic, and diabetic treated with carnosine (100 mg/kg). Diabetes was induced by streptozotocin (STZ) at a dose of 60 mg/kg. L-carnosine was injected i.p. at a dose of 100 mg/kg one week after STZ injection for 8 weeks. Blood sample was taken from retro-orbital plexus before STZ injection and 4 and 8 weeks after STZ injection to measure blood glucose level. Passive avoidance and Y maze tests were done to assess learning and memory deficits. Results: After 8 weeks, diabetic rats showed a significant cognitive dysfunction in passive avoidance and Y maze tests that was significantly attenuated following carnosine treatment. In addition, carnosine showed a hypoglycemic effect. Conclusion: This study demonstrated that treatment with carnosine for 8 weeks could improve cognitive functions in diabetic condition and part of its beneficial effect is due to its reduction of blood glucose.
نویسندگان
Faegheh Mousavi
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Ali Haeri Rohani
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mohsen Khalili
Neurophysiology Research Center, Shahed University, Tehran, Iran
Mehrdad Roghani
Neurophysiology Research Center, Shahed University, Tehran, Iran